91 research outputs found

    Serum Substitute Medium for Bone Tissue Engineering Applications

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    Serum Substitute Medium for Bone Tissue Engineering Applications

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    Review Manipulation: Literature Review, and Future Research Agenda

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    Background: The phenomenon of review manipulation and fake reviews has gained Information Systems (IS) scholars’ attention during recent years. Scholarly research in this domain has delved into the causes and consequences of review manipulation. However, we find that the findings are diverse, and the studies do not portray a systematic approach. This study synthesizes the findings from a multidisciplinary perspective and presents an integrated framework to understand the mechanism of review manipulation. Method: The study reviews 88 relevant articles on review manipulation spanning a decade and a half. We adopted an iterative coding approach to synthesizing the literature on concepts and categorized them independently into potential themes. Results: We present an integrated framework that shows the linkages between the different themes, namely, the prevalence of manipulation, impact of manipulation, conditions and choice for manipulation decision, characteristics of fake reviews, models for detecting spam reviews, and strategies to deal with manipulation. We also present the characteristics of review manipulation and cover both operational and conceptual issues associated with the research on this topic. Conclusions: Insights from the study will guide future research on review manipulation and fake reviews. The study presents a holistic view of the phenomenon of review manipulation. It informs various online platforms to address fake reviews towards building a healthy and sustainable environment

    FAKE REVIEWS AND MANIPULATION: DO CUSTOMER REVIEWS MATTER?

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    With the prevalence of fake reviews across web and e-commerce platforms it has become difficult for the customers to make an informed purchase decision. Considering this we examine the influence of review manipulation on customer’s purchase decision. A qualitative approach employing interviews with frequent online shoppers was employed to explore the phenomenon. The results of the study suggest that customers accord recommendations from their social network more weightage than the reviews available on an e-commerce platform. Further, we found that customers apply either or both interactive and extractive strategies to deal with review manipulation. Keywords: information processing, review manipulation, fake reviews, grounded theory

    Development of serum substitute medium for bone tissue engineering

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    In tissue engineering, cells are grown often on scaffolds and subjected to chemical/mechanical stimuli. Most such cultures still use fetal bovine serum (FBS) despite its known disadvantages including ethical concerns, safety issues, and variability in composition, which greatly influences the experimental outcomes. To overcome the disadvantages of using FBS, chemically defined serum substitute medium needs to be developed. Development of such medium depends on cell type and application—which makes it impossible to define one universal serum substitute medium for all cells in any application. Here, we developed a serum substitute medium for bone tissue engineering (BTE) in a step-by-step process. Essential components were added to the medium while human bone marrow mesenchymal stromal cells (hBMSCs, osteoblast progenitor cells) were cultured in two-dimensional and three-dimensional substrates. In a 3-week culture, the developed serum substitute medium worked equally well as FBS containing medium in term of cell attachment to the substrate, cell survival, osteoblast differentiation, and deposition of extracellular matrix. In the next step, the use of serum substitute medium was evaluated when culturing cells under mechanical loading in the form of shear stress. The outcomes showed that the application of shear stress is essential to improve extracellular matrix formation while using serum substitute medium. The developed serum substitute medium could pave the way in replacing FBS for BTE studies eliminating the use of controversial FBS and providing a better-defined chemical environment for BTE studies.</p

    Do Customers Perceive Reviews as Manipulated? A Warranting Theory Perspective

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    Online customer reviews proved to have an influence on customer’s purchase. However, most online reviews don’t always prove effective in guiding the purchase process, because of fake reviews. While e-commerce platforms do tend to incorporate ways to counter review manipulation, customer perception on review quality is more important. In this study we aim to understand the impression mechanism of online reviews. Using warranting theory, as theoretical lens we found that textual and review characteristics play a crucial role in forming an impression amongst the customers. Further, research suggest that higher contamination of reviews influence customers to perceive reviews less authentic

    Outcome of different modes of non-invasive ventilation in chronic obstructive pulmonary disease patients with type II respiratory failure

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    Background: Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory airway disorder often leading to type II respiratory failure (RF). Non-invasive ventilation (NIV) is crucial in COPD management. This study compares T (Timed), ST (Spontaneous-Timed), and iVAPS (Intelligent volume assured pressure support) modes. Method: A prospective, experimental, comparative study spanned two years. One hundred COPD patients with Type 2 RF were randomized into three groups: T mode (n=33), ST mode (n=33), and iVAPS mode (n=34). Outcome assessment included clinical, hematological parameters, and intubation rate. Result: The study revealed varying degrees of success among the three modes of NIV. iVAPS mode demonstrated the highest success rate, with 79.4% of cases achieving positive outcomes. Noteworthy improvements were observed in respiratory rate (RR) and oxygen saturation (SpO2) in the iVAPS group after 12 hours of NIV. Both the ST mode and iVAPS mode showed significant increases in pH levels, with a more pronounced improvement seen in the iVAPS group. Additionally, a substantial reduction in pCO2 levels after BiPAP was noted in the iVAPS group. The intubation rate was lowest in the iVAPS group, though the difference did not reach statistical significance. Conclusions: iVAPS mode demonstrated superior outcomes, including significant improvements in RR, SpO2, pH, and pCO2. While the intubation rate was lowest in the iVAPS group, statistical significance was not achieved. iVAPS emerges as a promising alternative, potentially averting the need for invasive ventilation. Larger, diverse studies are needed to validate these findings

    Hearing Loss in Chronic Otitis Media Mucosal Type, Does This Have a Relation with Patient Demographic Profile, a Study in the Third World Country

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    The study was conducted to establish a relationship between hearing loss withthe demographic profile in patients with chronic otitis media inactive mucosal disease. Patients with chronic otitis media (COM) inactive mucosal disease, of both sexes and different age groups were assessed and grouped based on unilateral or bilateral ear involvement; rural and urban, and based on the duration of discharge. Hearing loss (HL) was measured by calculating the air-bone gap via pure-tone audiometry. The study included 210 ears, a total of 161 patients. The age group of patients ranged from 15 to 55 years. Maximum proportion (53 %) in younger age groups (15-25 years) but no relation with HL was seen. Incidence was higher in females, with significantly greater HL. Greater HL in bilateral involvement. 51% right ear and 49% left ear involvement; 59 % from the rural area, 41 % from urban areas; no significant difference in HL. Duration of ear discharge varied from2 months to several years; maximum proportion (41%) for more than 10 years, with maximum HL (27.18 dB). Hence, it was concluded that high incidence of COM was in patients in the younger age range, in females, in rural areas, and in unilateral ear involvement. HL was significantly higher with bilateral involvement and in the female population. Greater HL was associated with longer discharging ears.Lattice Science Publication (LSP) © Copyright: All rights reserved

    Ectopic parathyroid adenoma: A case report

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    The parathyroid adenoma can be located in an "ectopic" situation in 10% of cases, secondary to "embryonic migration" anomalies. Retroclavicular location of an ectopic parathyroid adenoma is exceptional. Therefore, its diagnosis can be particularly difficult. We report the case of a 51-year-old female patient with no previous history who consulted for asymptomatic hypercalcemia and whose investigations, in particular Technetium Tc 99m Sestamibi scintigraphy, revealed a right retroclavicular parathyroid adenoma measuring 2.7x3.2 cm in an ectopic situation, confirmed on histological examination after surgery

    An Exploration of Unani Concept of Pain with Conventional Medicine

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    The intention of medicine is to retain and restore health and relieve suffering. Understanding pain is essential to achieving any one of these goals. It is irrefutable that every individual experiences pain in their life and is one of the commonest manifestations a physician encounters in their career. Pain makes sufferers and physicians aware of the presence of some disorders. This is the primary steps for the physician to protect the body from diseases and restore health. In addition, there is a close relationship between pain and psychological state. Pain can arise either as a consequence of physical problem or because of a psychological process. Aristotle, who associated pain with sensation, observed that where there is a sensation, there is pleasure and pain too. In addition, apparently, he regarded pain as a qualifying sensation. Relevant literary material for this paper was collected from classical Unani literature as well as modern medicine. Then, available literary material was analysed and organized systematically. This review article aims to provide a breeding ground for reflection on the concept of pain according to the Unani system of medicine and to encourage the identification of a meaningful aspect of this complex condition
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